ChinaOncologyInjection DESCRIPTION Pegfilgrastim is a covalent conjugate of recombinant methionyl human G-CSF (filgrastim) and monomethoxypolyethylene glycol. Filgrastim is a water soluble 175 amino acid protein with a molecular weight of approximately 19 kilodaltons (kD). Filgrastim is obtained from the bacterial fermentation of a strain of E coli transformed with a genetically engineered plasmid containing the human G-CSF gene. To produce pegfilgrastim, a 20 kD monomethoxy polyethylene glycol molecule is covalently bound to the N-terminal methionyl residue of filgrastim. The average molecular weight of pegfilgrastim is approximately 39 kD. Neulasta is provided in two presentations: Neulasta for manual subcutaneous injection is supplied in 0.6 mL prefilled syringes. The prefilled syringe does not bear graduation marks and is designed to deliver the entire contents of the syringe (6 mg/0.6 mL). On-body injector (OBI) for Neulasta is supplied with a prefilled syringe containing 0.64 mL of Neulasta in solution that delivers 0.6 mL of Neulasta in solution when used with the OBI for Neulasta. The syringe does not bear graduation marks and is only to be used with the OBI for Neulasta. The delivered 0.6 mL dose from either the prefilled syringe for manual subcutaneous injection or the OBI for Neulasta contains 6 mg pegfilgrastim (based on protein weight) in a sterile, clear, colorless, preservative-free solution (pH 4.0) containing acetate (0.35 mg), polysorbate 20 (0.02 mg), sodium (0.02 mg), and sorbitol (30 mg) in Water for Injection, USP. Mechanism of Action Pegfilgrastim is a colony-stimulating factor that acts on hematopoietic cells by binding to specific cell surface receptors, thereby stimulating proliferation, differentiation, commitment, and end cell functional activation. Pharmacodynamics Animal data and clinical data in humans suggest a correlation between pegfilgrastim exposure and the duration of severe neutropenia as a predictor of efficacy. Selection of the dosing regimen of Neulasta is based on reducing the duration of severe neutropenia. Name: Pegfilgrastim Pegfilgrastim (pegfilgrastim) is a colony-stimulating factor, a man-made form of a protein that stimulates the growth of white blood cells, used to decrease the incidence of infection, by treating neutropenia, a lack of certain white blood cells caused by receiving cancer chemotherapy. Dosage: Injection Specification 6mg: 6ml Indications Patients With Cancer Receiving Myelosuppressive Chemotherapy Pegfilgrastim is indicated to decrease the incidence of infection, as manifested by febrile neutropenia, in patients with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a clinically significant incidence of febrile neutropenia . Hangzhou Jiuyuan is a top-biotech joint venture specializing in the research, development, manufacture, and marketing of pharmaceuticals based on gene engineering and biochemical technology since 1993. It has gene engineering workshops, injection workshops, pharmaceutical API workshops, and other sections including the quality management department, warehouse, engineering department, etc., all of which are built according to GMP requirements. Jiuyuan is equipped with advanced production and analysis instruments like chromatography systems, HPLC, and capillary electrophoresis. We offer high-quality products and comprehensive sales services, please contact us. Focus on the enterprise purpose of "Take gene engineering as orientation, Render service to human health", the company adheres to serving the Chinese market as the main body and supporting some foreign markets as the auxiliary. Jiuyuan Marketing cultivates a professional, dedicated, and enterprising pharmaceutical service team establishes a stable, credible, and efficient pharmaceutical service network, and focuses on timely delivery of high-quality pharmaceutical products which are the crystallization of scientific research, quality control, and production, to the patients in urgent need, and efficient operation for safe, effective and economic use. We have been pursuing to improve professional pharmaceutical service skills, expand the radiation capacity of the pharmaceutical service network, and it is our constant pursuit to make Jiuyuan Pharmaceutical products and medical devices to serve human health. Company Honor National New High-tech Enterprise Key New High-tech Enterprise of National Torch Plan National superior enterprise of intellectual property Provincial New High-tech Research Development Center Zhejiang Provincial Enterprise Technology Center Zhejiang Famous Trademark Zhejiang Jiuyuan Gene Engineering Biopharmaceutical Research Institute FAQ Q: When can I get the price? A: Usually we quote within 8 hours after we get your inquiry. Q: What's your MOQ? A: If we have the products in stock, it will be no MOQ. If we need to produce, we can discuss the MOQ according to customer's exact situation. Q: How long is your delivery time? A: The general delivery time is 30-45 days after receiving your order confirmation. if we have the goods in stock, it will only take 1-2 days. Q: Do you provide sample? Is it free? A: If the sample is low value, we will provide the free sample with freight collect. But for some high value samples, we need to collect the sample charge. Q: What is your term of payment? A: 30% down payment before producing and 70% balance payment before shipping. Our Services 1. Good knowledge on different market can meet special requirements. 2. Real manufacturer with our own factory located in China 3. Strong professional technical team ensure to produce the top quality products. 4. Special cost control system ensure to provide the most favorable price. 5. Rich experience on drug.ChinaOncologyInjection website:http://www.jiuyuangene.net/finished-dosage-form/oncology-injection/